Ohio State football vs. Big 12
Even with all of the conference realignment happening in the Big 12, the Buckeyes have played every team in the conference except for two of them.
Kansas: The worst football program in the Big 12 bar none and perhaps one of the bottom ten programs in the country. It doesn’t makes sense for the Buckeyes to ever want the Jayhawks on their schedule. It would just be a bloodbath to watch.
Iowa State: Having played Iowa so frequently, I’m a little surprised the Cyclones have never come to the Shoe before. This is a team that could be scheduled in the future either for a home-and-home or for a neutral-site game as the Buckeyes did with TCU a few years ago.
All of the other schools in the Big 12 have seen the Buckeyes in either the regular season or in a Bowl game at some point.