
Who has the biggest uphill battle after a tough loss in the first [two] weeks? (such as Mich[igan], Miami [FL])
A: Michigan, win or lose in South Bend, has a gauntlet of a schedule this season so I will give them a pass with regard to this question.
I will go off the radar and say Florida State. The Willie Taggart era got off to a very rocky start as they were manhandled by Virginia Tech in front of their home crowd.
They followed up their lackluster performance with needing to come from behind to beat an FCS team Samford. The Seminoles still have the likes of Clemson, Miami, Notre dame, and Florida on their schedule.